tert-Butyl 4'-(bromomethyl)biphenyl-2-carboxylate → Diethyl 1-[(2'-t-butoxycarbonylbiphenyl-4-yl)methyl]-2-propylimidazole-4,5-dicarboxylate

Participants

Role	Name	HCID	Charge
Reactant	tert-Butyl 4'-(bromomethyl)biphenyl-2-carboxylate	HCID 9906257	—
Reactant	1H-Imidazole-4,5-dicarboxylic acid, 2-propyl-, 4,5-diethyl ester	HCID 10286015	—
Reactant	Potassium tert-butoxide	HCID 23665647	—
Product	Diethyl 1-[(2'-t-butoxycarbonylbiphenyl-4-yl)methyl]-2-propylimidazole-4,5-dicarboxylate	HCID 10768304	89.4%

Reaction Steps

Following a procedure similar to that described in Example 1(a), but using 9.0 g of diethyl 2-propylimidazole-4,5-dicarboxylate (prepared as described in Preparation 12), 12.3 g of t-butyl 4'-bromomethylbiphenyl-2-carboxylate and 4.1 g of potassium t-butoxide as a base. 16.47 g of the title compound were obtained as a viscous oil.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US05646171
Source dataset	uspto-grants-1997_07
ORD ID	ord-a27ac930d3e64f438cefabba153d70b7
Source note	uspto-grants-1997_07