HRID265092

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID168937

Lithium hydroxide, monohydrate

H3LiO2

结构：CCCc1nc(C(O)C(C)(C)C)c(C(=O)OCC)n1Cc1ccc(-c2ccccc2C(=O)OC(C)(C)C)cc1

HCID19036186

未命名化合物

PRODUCTS

生成物

结构：CCCc1nc(C(O)C(C)(C)C)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)OC(C)(C)C)cc1

HCID19036116

未命名化合物

收率 83.9%

PROCEDURE

实验过程

Following a procedure similar to that described in Example 4, 0.78 g of ethyl 1-[(2'-t-butoxycarbonylbiphenyl-4-yl)methyl]-4-(1-hydroxy-2,2-dimethylpropyl)-2-propylimidazole-5-carboxylate [prepared as described in step (d) above] was hydrolyzed, using 209 mg of lithium hydroxide monohydrate, to afford 0.62 g of the title compound as crystals, melting at 207° C.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-fd4e51a18bcf4afbb406958f86c8a6ac
来源数据集: uspto-grants-1997_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05646171
来源说明: uspto-grants-1997_07

反应 SMILES

[C:1]([O:5][C:6]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[C:14]1[CH:19]=[CH:18][C:17]([CH2:20][N:21]2[C:25]([C:26]([O:28]CC)=[O:27])=[C:24]([CH:31]([OH:36])[C:32]([CH3:35])([CH3:34])[CH3:33])[N:23]=[C:22]2[CH2:37][CH2:38][CH3:39])=[CH:16][CH:15]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2].O.[OH-].[Li+]>>[C:1]([O:5][C:6]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[C:14]1[CH:19]=[CH:18][C:17]([CH2:20][N:21]2[C:25]([C:26]([OH:28])=[O:27])=[C:24]([CH:31]([OH:36])[C:32]([CH3:35])([CH3:34])[CH3:33])[N:23]=[C:22]2[CH2:37][CH2:38][CH3:39])=[CH:16][CH:15]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2]