HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Cyano-4-Propionyl-2-propyl-1-tritylimidazole → 5-Cyano-4-(1-hydroxy-1-methylpropyl)-2-propyl-1-tritylimidazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Cyano-4-Propionyl-2-propyl-1-tritylimidazole | HCID 19036223 | — |
| Reactant | HCID 178418573 | HCID 178418573 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 5-Cyano-4-(1-hydroxy-1-methylpropyl)-2-propyl-1-tritylimidazole | HCID 19036146 | — |
Reaction Steps
Following the procedure described in Preparation 17, but using 5.00 g of 5-cyano-4-propionyl-2-propyl-1-tritylimidazole (prepared as described in Preparation 16) and 12.5 ml of a 1M solution of methylmagnesium bromide in tetrahydrofuran, 3.32 g of the title compound were obtained as a crystalline powder, melting at above 120° C. (softening at 110° C.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05646171 |
| Source dataset | uspto-grants-1997_07 |
| ORD ID | ord-2a6c31fd12df45019691344380bc226a |
| Source note | uspto-grants-1997_07 |