5-Cyano-4-Propionyl-2-propyl-1-tritylimidazole → 5-Cyano-4-(1-hydroxy-1-methylpropyl)-2-propyl-1-tritylimidazole

HRID 265168Notes

Reaction equation

HRID 265168 reaction equation
[C:1]([C:3]1[N:7]([C:8]([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[C:6]([CH2:27][CH2:28][CH3:29])=[N:5][C:4]=1[C:30](=[O:33])[CH2:31][CH3:32])#[N:2].[CH3:34][Mg]Br>O1CCCC1>[C:1]([C:3]1[N:7]([C:8]([C:15]2[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=2)([C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=2)[C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[C:6]([CH2:27][CH2:28][CH3:29])=[N:5][C:4]=1[C:30]([OH:33])([CH3:34])[CH2:31][CH3:32])#[N:2]

Participants

4

Reactant 2

HCID 190362235-Cyano-4-Propionyl-2-propyl-1-tritylimidazoleHCID 178418573HCID 178418573, compound

Product 1

HCID 190361465-Cyano-4-(1-hydroxy-1-methylpropyl)-2-propyl-1-tritylimidazole

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Following the procedure described in Preparation 17, but using 5.00 g of 5-cyano-4-propionyl-2-propyl-1-tritylimidazole (prepared as described in Preparation 16) and 12.5 ml of a 1M solution of methylmagnesium bromide in tetrahydrofuran, 3.32 g of the title compound were obtained as a crystalline powder, melting at above 120° C. (softening at 110° C.).

Workup

  1. customdescribed in Preparation 17

Sources & evidence

ORD record
ord-2a6c31fd12df45019691344380bc226a
Source dataset
uspto-grants-1997_07
Patent number
US05646171

Reaction notes

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