HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzyl Bromide → Diethyl 1-benzyl-2-ethylimidazole-4,5-dicarboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzyl Bromide | HCID 7498 | — |
| Reactant | 2-ethyl-1H-imidazole-4,5-dicarboxylic acid diethyl ester | HCID 19036267 | — |
| Product | Diethyl 1-benzyl-2-ethylimidazole-4,5-dicarboxylate | HCID 19036266 | — |
Reaction Steps
Following a procedure similar to that described in Preparation 42(i), 4.00 g of diethyl 2-ethylimidazole-4,5-dicarboxylate were benzylated, using 2.20 ml of benzyl bromide. The product was purified by column chromatography through silica gel, using a 1:1 by volume mixture of methylene chloride and ethyl acetate as the eluent, to give 5.19 g of the title compound as a syrup.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05646171 |
| Source dataset | uspto-grants-1997_07 |
| ORD ID | ord-9f32da11a8e3463391fc86307680c25d |
| Source note | uspto-grants-1997_07 |