HCID 21993065, compound → HCID 15789650, compound

HRID 265225Notes

Reaction equation

HRID 265225 reaction equation
C([NH:5][S:6]([C:9]1[CH:14]=[C:13]([CH2:15][NH:16][C:17](=[O:19])[CH3:18])[CH:12]=[CH:11][C:10]=1[C:20]([O:22][CH3:23])=[O:21])(=[O:8])=[O:7])(C)(C)C>FC(F)(F)C(O)=O>[C:17]([NH:16][CH2:15][C:13]1[CH:12]=[CH:11][C:10]([C:20]([O:22][CH3:23])=[O:21])=[C:9]([S:6]([NH2:5])(=[O:7])=[O:8])[CH:14]=1)(=[O:19])[CH3:18]

Participants

3

Reactant 1

HCID 21993065HCID 21993065, compound

Product 1

HCID 15789650HCID 15789650, compoundYield 76.2%

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

A solution of 2.09 g (6.1 mmol) of N-tert-butyl-5-acetamidomethyl-2-methoxycarbonylbenzenesulfonamide in 25 ml of trifluoroacetic acid is stirred at room temperature for 14 h and then evaporated to dryness. Crystallization of the residue from ethyl acetate yields 1.33 g (76%) of 5-acetamidomethyl-2-methoxycarbonylbenzenesulfonamide of mp. 173°-175° C.

Workup

  1. customevaporated to dryness
  2. customCrystallization of the residue from ethyl acetate

Sources & evidence

ORD record
ord-2b4f5083487f4b639b6125adf63e49ed
Source dataset
uspto-grants-1997_07
Patent number
US05648315

Reaction notes

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