1-(3,4-Difluorophenyl)-1-propanone → 2-Bromo-1-(3,4-difluorophenyl)propan-1-one

HRID 265232Notes

Reaction equation

HRID 265232 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C:9](=[O:12])[CH2:10][CH3:11])[CH:5]=[CH:6][C:7]=1[F:8].[Br-:13].[Br-].O1CCOCC1>O1CCOCC1>[Br:13][CH:10]([CH3:11])[C:9]([C:4]1[CH:5]=[CH:6][C:7]([F:8])=[C:2]([F:1])[CH:3]=1)=[O:12]

Participants

4

Reactant 2

HCID 5200501-(3,4-Difluorophenyl)-1-propanoneHCID 222259191,4-Dioxane dibromide

Product 1

HCID 152812742-Bromo-1-(3,4-difluorophenyl)propan-1-oneYield 98.9%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To 3',4'-difluoropropiophenone (Alfa Products, Danvers, Mass. 01923) (90.5 g, 0.53 mole) was added a solution of dioxane dibromide (131 4 g, 0.53 mole) in dioxane (500 ml). The reaction was worked up as in Example 1 to yield crude 2-bromo-3',4'-difluoropropiophenone (130.5 g).

Sources & evidence

ORD record
ord-8081e874fe1d4a1aa24c39bb080b92b2
Source dataset
uspto-grants-1997_07
Patent number
US05648347

Reaction notes

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