反应详情

A mixture of 3-(1-(1H)-imidazolyl)-1-(4-trifluoromethylphenyl)1-propanone (4.65 g), O-(2-aminoethyl)hydroxylamine dihydrochloride (3.10 g), 3 equivalents of pyridine, and absolute ethanol (75 ml) was heated under reflux, under nitrogen, with stirring, for two hrs. The reaction mixture was diluted with 10% sodium hydroxide solution and ethyl acetate. The layers were separated. The aqueous phase was extracted with ethyl acetate, the organic layers were dried over anhydrous sodium sulfate, filtered, and the filtrate was evaporated. The residue was taken up in toluene and evaporated. The residue was flash chromatographed (180:19:1 dichloromethane/methanol/ammonium hydroxide). The appropriate fractions were collected and concentrated. The residue was dissolved in absolute ethanol and treated with ethereal hydrogen chloride. Diethyl ether was added to the solution. The solid was collected and recrystallized twice from absolute ethanol/ether to give 2.8 g (40%) of product, mp 213°-214° C. (dec).

1. temperaturewas heated
2. temperatureunder reflux, under nitrogen
3. customThe layers were separated
4. extractionThe aqueous phase was extracted with ethyl acetate
5. dry with materialthe organic layers were dried over anhydrous sodium sulfate
6. filtrationfiltered
7. customthe filtrate was evaporated
8. customevaporated
9. customchromatographed (180:19:1 dichloromethane/methanol/ammonium hydroxide)
10. customThe appropriate fractions were collected
11. concentrationconcentrated
12. dissolutionThe residue was dissolved in absolute ethanol
13. additiontreated with ethereal hydrogen chloride
14. additionDiethyl ether was added to the solution
15. customThe solid was collected
16. customrecrystallized twice from absolute ethanol/ether