Hydrochloric Acid → HCID 19082247, compound

HRID 265286Notes

Reaction equation

HRID 265286 reaction equation
Cl.C[O:3][C:4]1[S:5][C:6]2[C:12]([CH2:13][CH2:14][NH:15][C:16](=[O:32])[CH2:17][CH2:18][S:19][CH2:20][C:21](=[O:31])[NH:22][CH2:23][CH2:24][C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=3)=[CH:11][CH:10]=[C:9]([O:33][CH3:34])[C:7]=2[N:8]=1>CO>[CH3:34][O:33][C:9]1[C:7]2[NH:8][C:4](=[O:3])[S:5][C:6]=2[C:12]([CH2:13][CH2:14][NH:15][C:16](=[O:32])[CH2:17][CH2:18][S:19][CH2:20][C:21](=[O:31])[NH:22][CH2:23][CH2:24][C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)=[CH:11][CH:10]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 19082262HCID 19082262, compound

Product 1

HCID 19082247HCID 19082247, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Conc. hydrochloric acid (sg. 1.18, 1.5 ml) was added to the compound from step b) (3.3 g) in methanol (30 ml) and the mixture stirred at room temperature overnight. The solvent was evaporated under reduced pressure and the residue partitioned between chloroform and water. The organic layer was separated and the aqueous layer extracted with dichloromethane. The combined organic extracts were dried (MgSO4) and the solvents removed under reduced pressure to give the subtitled compound as an orange oil.

Workup

  1. customThe solvent was evaporated under reduced pressure
  2. customthe residue partitioned between chloroform and water
  3. customThe organic layer was separated
  4. extractionthe aqueous layer extracted with dichloromethane
  5. dry with materialThe combined organic extracts were dried (MgSO4)
  6. customthe solvents removed under reduced pressure

Sources & evidence

ORD record
ord-09d4e2760e394bb9903c5d8fc2c8ac4f
Source dataset
uspto-grants-1997_07
Patent number
US05648370

Reaction notes

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