Sodium Methoxide → 3,8-dimethoxy-11H-s-triazolo[3,4-b][3]benzazepine

HRID 26529Notes

Reaction equation

[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]2[CH2:12][C:11]3=[N:13][N:14]=[C:15](S(C)(=O)=O)[N:10]3[CH:9]=[CH:8][C:7]=2[CH:20]=1.[CH3:21][O-:22].[Na+]>>[CH3:21][O:22][C:15]1[N:10]2[C:11]([CH2:12][C:6]3[CH:5]=[CH:4][C:3]([O:2][CH3:1])=[CH:20][C:7]=3[CH:8]=[CH:9]2)=[N:13][N:14]=1

Participants

Reactant 2

HCID 10942334Sodium Methoxide

HCID 213234198-methoxy-3-methylsulfonyl-11H-s-triazolo[3,4-b][3]benzazepine

Product 1

HCID 213234163,8-dimethoxy-11H-s-triazolo[3,4-b][3]benzazepine

Procedure

The reaction of 8-methoxy-3-methylsulfonyl-11H-s-triazolo[3,4-b][3]benzazepine with sodium methoxide yielded 3,8-dimethoxy-11H-s-triazolo[3,4-b][3]benzazepine. Colorless needles (as recrystallized from aqueous methanol), melting point: 185°-186° C.

Sources & evidence

ORD record: ord-bb3a1619fd494254a6f9b916788ada72
Source dataset: uspto-grants-1979_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04150139

Reaction notes

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