7-(2-Aminoethyl)-4-hydroxy-1,3-benzothiazol-2(3H)-one hydrobromide → 2,2-Difluoro-N-[2-[4-hydroxy-2-oxo-3H-1,3-benzothiazol-7-yl]ethyl]-6-[2-phenylethoxy]hexanamide

HRID 265290Notes

Reaction equation

HRID 265290 reaction equation
[F:1][C:2]([F:19])([CH2:6][CH2:7][CH2:8][CH2:9][O:10][CH2:11][CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[C:3]([OH:5])=O.Br.[NH2:21][CH2:22][CH2:23][C:24]1[C:32]2[S:31][C:30](=[O:33])[NH:29][C:28]=2[C:27]([OH:34])=[CH:26][CH:25]=1>>[F:19][C:2]([F:1])([CH2:6][CH2:7][CH2:8][CH2:9][O:10][CH2:11][CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[C:3]([NH:21][CH2:22][CH2:23][C:24]1[C:32]2[S:31][C:30](=[O:33])[NH:29][C:28]=2[C:27]([OH:34])=[CH:26][CH:25]=1)=[O:5]

Participants

3

Reactant 2

HCID 138142707-(2-Aminoethyl)-4-hydroxy-1,3-benzothiazol-2(3H)-one hydrobromideHCID 190822142,2-Difluoro-6-[2-phenylethoxy]hexanoic acid

Product 1

HCID 190821992,2-Difluoro-N-[2-[4-hydroxy-2-oxo-3H-1,3-benzothiazol-7-yl]ethyl]-6-[2-phenylethoxy]hexanamide

Procedure

The subtitled compound was prepared by the method outlined in Example 15a) using the material from step c) and 7-[2-aminoethyl]-4-hydroxy-1,3-benzothiazol-2(3H)-one hydrobromide.

Sources & evidence

ORD record
ord-b1e593c6318547cd8708df32f080c44e
Source dataset
uspto-grants-1997_07
Patent number
US05648370

Reaction notes

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