Sodium ethoxide → 3-ethoxy-11H-s-triazolo[3,4-b][3]benzazepine

HRID 26533Notes

Reaction equation

Br[C:2]1[N:11]2[C:5]([CH2:6][C:7]3[CH:15]=[CH:14][CH:13]=[CH:12][C:8]=3[CH:9]=[CH:10]2)=[N:4][N:3]=1.[O-:16][CH2:17][CH3:18].[Na+]>>[CH2:17]([O:16][C:2]1[N:11]2[C:5]([CH2:6][C:7]3[CH:15]=[CH:14][CH:13]=[CH:12][C:8]=3[CH:9]=[CH:10]2)=[N:4][N:3]=1)[CH3:18]

Participants

Reactant 2

HCID 2723922Sodium ethoxide

HCID 213233903-bromo-11H-s-triazolo[3,4-b][3]benzazepine

Product 1

HCID 213233563-ethoxy-11H-s-triazolo[3,4-b][3]benzazepine

Procedure

The reaction of 3-bromo-11H-s-triazolo[3,4-b][3]benzazepine with sodium ethoxide yielded 3-ethoxy-11H-s-triazolo[3,4-b][3]benzazepine. Colorless needles (as recrystallized from acetone), melting point: 143°-144° C. Infrared absorption spectrum of this compound was identical with that of the products obtained in Examples 35 and 36.

Sources & evidence

ORD record: ord-11b7ec08a91b419c9c8f28c777fe6b8d
Source dataset: uspto-grants-1979_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04150139

Reaction notes

Loading…