Hydrochloric Acid → 5-Hydroxyindan-1,2,3-trione, monohydrate

HRID 265345Notes

Reaction equation

HRID 265345 reaction equation
Br[CH:2]1[C:10](=[O:11])[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([OH:12])[CH:8]=2)[C:3]1=[O:13].Cl.CS(C)=[O:17]>>[OH2:11].[OH:12][C:7]1[CH:8]=[C:9]2[C:4](=[CH:5][CH:6]=1)[C:3](=[O:13])[C:2](=[O:17])[C:10]2=[O:11]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 679Dimethyl SulfoxideHCID 190342852-Bromo-5-hydroxyindan-1,3-dione

Product 1

HCID 218031995-Hydroxyindan-1,2,3-trione, monohydrate

Procedure

A solution of 0.01 mol of 2-bromo-5-hydroxyindan-1,3-dione in 10 ml dimethyl sulphoxide was heated to 80° C. for 30 minutes. 50 ml of a 1N hydrochloric acid solution was added, after which heating was continued for 30 minutes. The oily suspension obtained after cooling was extracted with ethyl ether. The organic phase was washed in water and dried over magnesium sulphate.

Workup

  1. temperatureafter which heating
  2. customThe oily suspension obtained
  3. temperatureafter cooling
  4. extractionwas extracted with ethyl ether
  5. washThe organic phase was washed in water
  6. dry with materialdried over magnesium sulphate

Sources & evidence

ORD record
ord-6294ded03b0c4240b751179effe7c5e1
Source dataset
uspto-grants-1997_07
Patent number
US05648381

Reaction notes

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