反应详情

A solution of 1,4,5-triphenyl-3-(7-bromoheptyl)-imidazol-2-one (1.47 g) and triisopropyl phosphite (3.12 g) in xylene (15 ml) was heated at reflux temperature for 48 hours. The solution was evaporated to an oil and chromatographed on silica gel (ethyl acetate/ethanol). The resulting oil was taken up in diethyl ether, filtered and evaporated to the titled compound as a clear oil (0.33 g; 19%) Found: C, 70.02; H, 7.53; N, 5.19%; C34H43N2O4P+1.5% H2O; Requires: C, 69.99; H, 7.60; N, 4.80%.

1. temperatureat reflux temperature for 48 hours
2. customThe solution was evaporated to an oil
3. customchromatographed on silica gel (ethyl acetate/ethanol)
4. filtrationfiltered
5. customevaporated to the titled compound as a clear oil (0.33 g; 19%) Found