反应详情

A mixture of 2,4,5-triphenylimidazole (11 g), ethyl 8-bromooctanoate (18.64 g), anhydrous potassium carbonate (51.3 g) and dry butanone (350 ml) was heated at reflux for 26 h. The cooled reaction mixture was filtered to remove inorganics and the filtrate was evaporated to dryness in vacuo. The residue was stirred in hexane and unreacted 2,4,5-triphenylimidazole was collected by filtration (3.1 g). The filtrate was cooled and a white precipitate was collected. Recrystallisation from hexane gave 1-(7-ethoxy-carbonyl-heptyl)-2,4,5-triphenylimidazole (8.37 g, 48.4%) as a white solid, m.p. 65°-7°.

1. temperaturewas heated
2. temperatureat reflux for 26 h
3. customThe cooled reaction mixture
4. filtrationwas filtered
5. customto remove inorganics
6. customthe filtrate was evaporated to dryness in vacuo
7. filtrationunreacted 2,4,5-triphenylimidazole was collected by filtration (3.1 g)
8. temperatureThe filtrate was cooled
9. customa white precipitate was collected
10. customRecrystallisation from hexane