反应详情

2-Methyl-4,5-diphenylimidazole (2.5 g) (J. Org. Chem., 1937, 2, 328) was reacted with sodium hydride (0.62 g) and ethyl 8-bromooctanoate (3.36 g) in a method similar to Example 12. Chromatography on silica gel eluted with a dichloromethane:ethanol gradient gave 1-(7-ethoxycarbonyl-heptyl)-2-methyl-4,5-diphenylimidazole (3.1 g, 72.1%) as an oil.

1. washChromatography on silica gel eluted with a dichloromethane