反应详情

温度

0 °C

To a stirred, ice-cooled slurry of 35 g. of imidazole in 25 ml. of dimethylformamide is added 24.9 g. of bromomethyl 2-naphthyl ketone. The mixture is stirred for 2 hours at 0° C., and then allowed to come to room temperature and stirred overnight. The solution is poured into water and the resulting sticky solid filtered off, washed with water and dissolved in benzene. Thereafter the resultant benzene solution is dried (azeotroped) to afford 1-(2-naphthoylmethyl)imidazole which is converted to its hydrochloride acid addition salt by addition of ethereal hydrogen chloride until precipitation is complete. The salt is crystallized by the addition of ethyl acetate and the resulting solid recrystallized from methanol/acetone to yield colorless needles of 1-(2-naphthoylmethyl)imidazole hydrochloride, m.p. 226°-228.5° C. (decomp.).

1. temperatureTo a stirred, ice-cooled slurry of 35 g
2. customto come to room temperature
3. stirringstirred overnight
4. filtrationthe resulting sticky solid filtered off
5. washwashed with water
6. dissolutiondissolved in benzene
7. dry with materialThereafter the resultant benzene solution is dried
8. custom(azeotroped)