反应详情

4,5-Bis(2-chlorophenyl)-1-(7-ethoxycarbonylheptyl)-imidazole (0.4 g) was reacted with 2N sodium hydroxide in a method similar to Example 10. Work-up and chromatography on silica gel eluted with a dichloromethane:methanol gradient followed by recrystallisation from dichloro-methane and hexane gave 1-(7-carboxyheptyl)-4,5-bis-(2-chlorophenyl)imidazole (0.25 g, 67%) as a white solid, m.p. 145°-6°.

1. washchromatography on silica gel eluted with a dichloromethane
2. custommethanol gradient followed by recrystallisation from dichloro-methane and hexane