HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 1-(7-Carboxyheptyl)-4,5-bis-(2-chlorophenyl)imidazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 4,5-Bis(2-chlorophenyl)-1-(7-ethoxycarbonyl-heptyl)imidazole | HCID 22916405 | — |
| Product | 1-(7-Carboxyheptyl)-4,5-bis-(2-chlorophenyl)imidazole | HCID 22916406 | 67% |
Reaction Steps
4,5-Bis(2-chlorophenyl)-1-(7-ethoxycarbonylheptyl)-imidazole (0.4 g) was reacted with 2N sodium hydroxide in a method similar to Example 10. Work-up and chromatography on silica gel eluted with a dichloromethane:methanol gradient followed by recrystallisation from dichloro-methane and hexane gave 1-(7-carboxyheptyl)-4,5-bis-(2-chlorophenyl)imidazole (0.25 g, 67%) as a white solid, m.p. 145°-6°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05648373 |
| Source dataset | uspto-grants-1997_07 |
| ORD ID | ord-cb045659157d419ba3bcccd0db8878b0 |
| Source note | uspto-grants-1997_07 |