Potassium Carbonate → Ethyl 8-(4,5-di-(4-bromophenyl)imidazol-1-yl)-octanoate

HRID 265387Notes

Reaction equation

HRID 265387 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:9]=[CH:10][NH:11][C:12]=2[C:13]2[CH:18]=[CH:17][C:16]([Br:19])=[CH:15][CH:14]=2)=[CH:4][CH:3]=1.Br[CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][C:28]([O:30][CH2:31][CH3:32])=[O:29].C([O-])([O-])=O.[K+].[K+]>CC(=O)CC>[Br:19][C:16]1[CH:17]=[CH:18][C:13]([C:12]2[N:11]=[CH:10][N:9]([CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][C:28]([O:30][CH2:31][CH3:32])=[O:29])[C:8]=2[C:5]2[CH:4]=[CH:3][C:2]([Br:1])=[CH:7][CH:6]=2)=[CH:14][CH:15]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 264813Ethyl 8-bromooctanoateHCID 543857734,5-Bis(4-bromophenyl)-1H-imidazole

Product 1

HCID 22916427Ethyl 8-(4,5-di-(4-bromophenyl)imidazol-1-yl)-octanoateYield 71.2%

Reagents, catalysts & solvents 1

HCID 6569Methyl Ethyl KetoneSolvent

Procedure

4,5-Di-(4-bromophenyl)imidazole (2.13 g) was treated with ethyl 8-bromooctanoate (2 g) and K2CO3 (0.5 g) in 2-butanone as described in Example 9 to give ethyl 8-(4,5-di-(4-bromophenyl)imidazol-1-yl)-octanoate (2.2 g, 52%) as a pale yellow oil.; Found: C, 55.13; H, 5.19; N, 5.18; Br; 28.76%; C28H28Br2N2O2 requires: C, 54.76; H, 5.15; N, 5.11; Br, 29.15%

Sources & evidence

ORD record
ord-0b205ec02e794f23b5382d4438839fb3
Source dataset
uspto-grants-1997_07
Patent number
US05648373

Reaction notes

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