4-Propyl-4-phenyl-4-silacyclohexanone → HCID 178418450, compound

HRID 2654Notes

Reaction equation

HRID 2654 reaction equation
C([Si:4]1([C:11]2[CH:16]=[CH:15]C=CC=2)[CH2:9][CH2:8][C:7](=O)[CH2:6][CH2:5]1)CC.Cl[C:18]1[CH:23]=[C:22]([F:24])[C:21]([Si](C)(C)C)=[C:20]([F:29])[CH:19]=1.Br[C:31]1[CH:36]=[C:35]([F:37])[C:34]([C:38]([F:41])=[CH:39][F:40])=[C:33]([F:42])[CH:32]=1>>[CH2:11]([Si@H:4]1[CH2:5][CH2:6][C@H:7]([C:18]2[CH:23]=[C:22]([F:24])[C:21]([C:31]3[CH:32]=[C:33]([F:42])[C:34]([C:38]([F:41])=[CH:39][F:40])=[C:35]([F:37])[CH:36]=3)=[C:20]([F:29])[CH:19]=2)[CH2:8][CH2:9]1)[CH2:16][CH3:15]

Participants

4

Reactant 3

HCID 118313174-Propyl-4-phenyl-4-silacyclohexanoneHCID 18935733(4-Chloro-2,6-difluorophenyl)trimethylsilaneHCID 538007914-Bromo-2,6-difluoro-1-(1,2-difluorovinyl)benzene

Product 1

HCID 178418450HCID 178418450, compound

Procedure

The general procedure of Example 35 was repeated using 4-propyl-4-phenyl-4-silacyclohexanone instead of 4-pentyl-4-phenyl-4-silacyclohexanone, 4-chloro-2,6-difluorophenyltrimethylsilane instead of 4-chlorophenyltrimethylsilane, and 4-bromo-2,6-difluoro-1-(1,2-difluorovinyl)benzene instead of 4-bromo-2,6-difluoro-1-(2,2-difluorovinyloxy)benzene, thereby obtaining the intended compound.

Workup

  1. customobtaining the intended compound

Sources & evidence

ORD record
ord-cbb6a7ae64f8437f8e6e1b614d3b6cc8
Source dataset
uspto-grants-1998_03
Patent number
US05730901

Reaction notes

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