反应详情

温度

50 °C

2-(8-Bromooctyl)-4,5-diphenyltriazole (7 g) in dimethylsulphoxide (220 ml) was added to a suspension of sodium cyanide (1 g) in dimethylsulphoxide (60 ml) over 15 minutes. The reaction mixture was stirred at 24° C. for 1 hour and at 50° C. for 2 hours. The cooled reaction mixture was poured into water (600 ml), extracted with diethyl ether (4×200 ml). The extracts were combined, washed with water (100 ml), dried over anhydrous magnesium sulphate and evaporated to dryness in vacuo. Column chromatography on silica gel eluted with a hexane:ethyl acetate gradient gave 2-(8-cyanooctyl)-4,5-diphenyl-triazole (5.6 g, 92%) as an oil.

1. customThe cooled reaction mixture
2. extractionextracted with diethyl ether (4×200 ml)
3. washwashed with water (100 ml)
4. dry with materialdried over anhydrous magnesium sulphate
5. customevaporated to dryness in vacuo
6. washColumn chromatography on silica gel eluted with a hexane