Hexamethyldisilazane → HCID 178504300, compound

HRID 265607Notes

Reaction equation

HRID 265607 reaction equation
[NH:1]1[CH:8]=[CH:7][C:5](N)=[N:4][C:2]1=[O:3].[CH3:9][Si:10]([CH3:17])([CH3:16])[NH:11][Si:12]([CH3:15])([CH3:14])[CH3:13].S([O-])([O-])(=O)=O.[NH4+].[NH4+]>>[CH3:9][Si:10]([N:11]([Si:12]([CH3:15])([CH3:14])[CH3:13])[C:8]1[CH:7]=[CH:5][NH:4][C:2](=[O:3])[N:1]=1)([CH3:17])[CH3:16]

Participants

4

Reactant 3

HCID 13838HexamethyldisilazaneHCID 6097028Ammonium SulfateHCID 178418229Cytosine

Product 1

HCID 178504300HCID 178504300, compound

Conditions

Temperature
10 °C

Procedure

To 5.9 g of cytosine were added 112 ml of hexamethyldisilazane and 25 mg of ammonium sulfate. The solution was heated to 120° C.-125° C. for 3 hours with stirring and the excess hexamethyldisilazane was subsequently removed. The resulting solid residue was reconstituted in 35 ml of dichloromethane and cooled to 10° C. to form a homogenous bis-trimethylsilylcytosine solution.

Workup

  1. temperatureThe solution was heated to 120° C.-125° C. for 3 hours
  2. customthe excess hexamethyldisilazane was subsequently removed

Sources & evidence

ORD record
ord-07728f5d948e40eb93e68ab632d120f4
Source dataset
uspto-grants-1997_07
Patent number
US05648473

Reaction notes

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