反应详情

To a solution of 2.38 g(6.98 moles) of N-(t-butoxycarbonyl)-N-benzyl-L-phenylalaninol from Example 11 in 3.8 mL (27.2 mmoles) of triethylamine at 10° C. was added a solution of 4.33 g (27.2 mmoles) of sulfur trioxide pyridine complex in 17 mL of dimethyl sulfoxide. The mixture was warmed to room temperature and stirred for one hour. Water (16 mL) was added and the mixture was extracted with 20 mL of ethyl acetate. The oragnic layer was washed with 20 mL of 5% citric acid, 20 mL of water, 20 mL of brine, dried over magnesium sulfate and filtered. The filtrate was concentrated under reduced pressure to give 2.37 g 100% yield) of N-(t-Butoxycarbonyl)-N-benzyl-L-phenylalaninal.

1. extractionthe mixture was extracted with 20 mL of ethyl acetate
2. washThe oragnic layer was washed with 20 mL of 5% citric acid, 20 mL of water, 20 mL of brine
3. dry with materialdried over magnesium sulfate
4. filtrationfiltered
5. concentrationThe filtrate was concentrated under reduced pressure