反应详情

Methylisocyanate (1.96 milliliters, 0.04 mole) was added dropwise to a thirty (30) milliliter solution of tetrahydrofuran (distilled from calcium hydride) containing the above mentioned 5-amino-3-methylisothiazole (5.0 grams, 0.04 mole), and then the resulting yellow solution was refluxed for 3 hours, during which time a white precipitate formed. The solution was cooled and filtered, giving 3.73 grams of 1-(3-methyl-5-isothiazolyl)-3-methylurea, also referred to as 3-methyl-5-N-methylureidoisothiazole.

1. additioncontaining the
2. temperaturethe resulting yellow solution was refluxed for 3 hours, during which time a white precipitate
3. customformed
4. temperatureThe solution was cooled
5. filtrationfiltered