HCID 54067858, compound → HCID 19034102, compound

HRID 265864Notes

Reaction equation

HRID 265864 reaction equation
[C:1]([N:8]1[CH2:13][CH2:12][C:11]([C:15]2[CH:20]=[CH:19][C:18]([CH:21]=[CH:22][C:23]([O:25][CH3:26])=[O:24])=[CH:17][CH:16]=2)([OH:14])[CH2:10][CH2:9]1)([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2]>CO.[Pd]>[C:1]([N:8]1[CH2:9][CH2:10][C:11]([C:15]2[CH:20]=[CH:19][C:18]([CH2:21][CH2:22][C:23]([O:25][CH3:26])=[O:24])=[CH:17][CH:16]=2)([OH:14])[CH2:12][CH2:13]1)([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2]

Participants

4

Reactant 1

HCID 54067858HCID 54067858, compound

Product 1

HCID 19034102HCID 19034102, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A solution of 10-4 (0.42 g, 1.16 mmoles) in MeOH (6 ml) was treated with 0.17 g 10% Pd/C and this was hydrogenated under 1 atm. of H2 pressure for 48 hours. Solvent removal and purification by flash chromatography on silica gel eluting with 50% EtOAc/hexanes gave pure 10-5. Rf 0.55 (silica, 50% EtOAc/hexanes).

Workup

  1. customSolvent removal and purification by flash chromatography on silica gel eluting with 50% EtOAc/hexanes
  2. customgave pure 10-5

Sources & evidence

ORD record
ord-0ba2d81e0c7a41af9616694c0eb1a9aa
Source dataset
uspto-grants-1997_07
Patent number
US05648368

Reaction notes

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