HCID 86751083, compound → HCID 86751082, compound

HRID 265867Notes

Reaction equation

HRID 265867 reaction equation
[NH:1]1[CH2:6][CH2:5][C:4]([C:7]2[CH:12]=[CH:11][C:10]([N:13]([NH:23][S:24]([C@H:27]([CH2:29][CH3:30])[CH3:28])(=[O:26])=[O:25])[CH:14]([C:19](=[O:22])[CH2:20][CH3:21])[CH2:15][C:16]([OH:18])=[O:17])=[CH:9][CH:8]=2)=[CH:3][CH2:2]1>CO.[Pd]>[NH:1]1[CH2:6][CH2:5][CH:4]([C:7]2[CH:8]=[CH:9][C:10]([N:13]([NH:23][S:24]([C@H:27]([CH2:29][CH3:30])[CH3:28])(=[O:26])=[O:25])[CH:14]([C:19](=[O:22])[CH2:20][CH3:21])[CH2:15][C:16]([OH:18])=[O:17])=[CH:11][CH:12]=2)[CH2:3][CH2:2]1

Participants

4

Reactant 1

HCID 86751083HCID 86751083, compound

Product 1

HCID 86751082HCID 86751082, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A solution of 10-14 (0.05 g, 0.114 mmoles) in CH3OH (1 ml) was treated with 10% Pd/C (25 mg) and then hydrogenated for 2 hours at 1 atom H2. The catalyst was then removed by filtration. The solution concentrated to give pure 10-15. Rf 0.3 (silica, EtOH(10)/H2O(1)/NH4OH(1).

Workup

  1. customThe catalyst was then removed by filtration
  2. concentrationThe solution concentrated
  3. customto give pure 10-15

Sources & evidence

ORD record
ord-7650813296a140c3b6f1f32704a9653f
Source dataset
uspto-grants-1997_07
Patent number
US05648368

Reaction notes

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