反应详情

A stirred mixture of 3-bromobenzyl bromide (Aldrich) (5.1 g, 20.5 mmoles), triphenylphosphine (54 g, 0.20 moles), and CH3CN (100 mL) was refluxed for 20 hours. The cooled reaction mixture was then concentrated and the residue triturated with hexanes (10×) to remove excess triphenylphosphine. The remaining white solid was collected by filtration and then dried in vacuo to give 11-2 as a white solid.

1. temperaturewas refluxed for 20 hours
2. customThe cooled reaction mixture
3. concentrationwas then concentrated
4. customthe residue triturated with hexanes (10×)
5. customto remove excess triphenylphosphine
6. filtrationThe remaining white solid was collected by filtration
7. customdried in vacuo