huagongshe.com
HRID265875

反应详情

EQUATION

反应方程式

HRID 265875 的结构方程式

REACTANTS

反应物

2
结构：O=C(O)C(F)(F)F
HCID6422

未命名化合物

结构：CC(CC(=O)NCCC(=O)OC(C)(C)C)c1ccc(C2CCN(C(=O)OC(C)(C)C)C(O)C2)cc1
HCID19034107

未命名化合物

PRODUCTS

生成物

2
结构：CC(CC(=O)NCCC(=O)O)c1ccc(C2=CCNCC2)cc1
HCID19034126

未命名化合物

结构：CCO.O.[NH4+].[OH-]
HCID86596525

Ethanol ammonium hydroxide water

C2H13NO3

AUXILIARIES

试剂、催化剂与溶剂

1
结构：ClCCl
溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

A mixture of 12-5 (120 mg, 0.25 mmoles), CH2Cl2 (1.0 mL), and TFA (1.0 mL) was stirred at ambient temperature for 4.0 hours and then concentrated with azeotropic removal of the excess TFA. Flash chromatography (silica, 10/1/1 ethanol/NH4OH/H2O/gave 12-6 as a white solid. Rf 0.13 (10/1/1 ethanol/NH4OH/H2O).

WORKUP

后处理

  1. concentrationconcentrated with azeotropic removal of the excess TFA