HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium hydroxide, monohydrate → 4'-Cyano[1,1'-biphenyl]-4-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium hydroxide, monohydrate | HCID 168937 | — |
| Reactant | Methyl 4-(4-cyanophenyl)benzoate | HCID 2764426 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Solvent | Methanol tetrahydrofuran water | HCID 21892291 | — |
| Product | 4'-Cyano[1,1'-biphenyl]-4-carboxylic acid | HCID 2757954 | — |
Reaction Steps
Compound 18-3 (3.4 g, 15.1 mmole), and LiOH·H2O (3.1 g, 75.5 mmol) were dissolved in THF/MeOH/H2O (30 mL/30 mL/30 mL) and stirred at room temperature overnight. The solution was diluted with EtOAc and washed with 10% KHSO4. The organic layer was washed with brine, dried over MgSO4, filtered and concentrated to yield 18-4 as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05648368 |
| Source dataset | uspto-grants-1997_07 |
| ORD ID | ord-adc7046b4d5547e6b0398afc88023ffc |
| Source note | uspto-grants-1997_07 |