反应详情

Compound 18-3 (3.4 g, 15.1 mmole), and LiOH·H2O (3.1 g, 75.5 mmol) were dissolved in THF/MeOH/H2O (30 mL/30 mL/30 mL) and stirred at room temperature overnight. The solution was diluted with EtOAc and washed with 10% KHSO4. The organic layer was washed with brine, dried over MgSO4, filtered and concentrated to yield 18-4 as a white solid.

1. washwashed with 10% KHSO4
2. washThe organic layer was washed with brine
3. dry with materialdried over MgSO4
4. filtrationfiltered
5. concentrationconcentrated