HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 265890Generated: October 25, 2026
Sodium Hydroxide → 4-[4-(tert-Butoxycarbonyl)piperazin-1-yl]benzoic acid
https://huagongshe.com/reaction/265890
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Potassium bisulfate | HCID 516920 | — |
| Reactant | 1-Boc-4-(4-methoxycarbonylphenyl)piperazine | HCID 2795513 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 4-[4-(tert-Butoxycarbonyl)piperazin-1-yl]benzoic acid | HCID 2795508 | — |
Reaction Steps
A mixture of 22-3 (700 mg, 2.2 mmol), 1N NaOH, and ethanol (10 mL) was heated at 40° C. for 4 hours. The cooled reaction mixture was acidified with 10% KHSO4 and then extracted with EtOAc. The organic portion was washed with brine, dried (MgSO4) and concentrated to give 22-4 as a white solid. TLC Rf =0.80 (silica, 10:0.5:0.5 CH2Cl2 /CH3OH/AcOH);
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05648368 |
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| Source dataset | uspto-grants-1997_07 |
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| ORD ID | ord-1ddb7e0c951248ec9b33ae5c1059cfd4 |
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| Source note | uspto-grants-1997_07 |
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