HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 265892Generated: October 26, 2026
Sodium Hydroxide → 4-(4-Chlorobutyloxy)benzoic acid
https://huagongshe.com/reaction/265892
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Potassium bisulfate | HCID 516920 | — |
| Reactant | Methyl 4-(4-chlorobutoxy)benzoate | HCID 14575308 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 4-(4-Chlorobutyloxy)benzoic acid | HCID 19034175 | — |
Reaction Steps
A mixture of 24-2 (3.0 g, 12.4 mmol), 1N NaOH (30 mL), and ethanol was heated at 60° C. for 1.0 hour. The cooled reaction mixture was acidified with 10% KHSO4 and then extracted with EtOAc. The EtOAc portion was washed with brine, dried (MgSO4) and concentrated to give 24-3 as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05648368 |
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| Source dataset | uspto-grants-1997_07 |
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| ORD ID | ord-21803ed5b24647c39e159b4ca30aa559 |
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| Source note | uspto-grants-1997_07 |
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