HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → Tert-butyl (2S)-3-amino-2-benzenesulfonamidopropanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Morpholine | HCID 8083 | — |
| Reactant | 4-(4-Chlorobutyloxy)benzoyl-2(S)-phenylsulfonylamino-beta-alanine tert-butylester | HCID 86751090 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | Tert-butyl (2S)-3-amino-2-benzenesulfonamidopropanoate | HCID 10804181 | — |
Reaction Steps
A stirring solution of 24-4 (500 mg, 1.0 mmol), morpholine (437 gL, 5.0 mmol), and DMF (5 mL) was heated at 80° C. for 20 hours. The cooled reaction mixture was diluted with EtOAc and then washed with H2O and brine, dried (MgSO4) and concentrated. Flash chromatography (silica, EtOAc) gave 24-5 as a yellow solid. TLC Rf 0.14 (silica, EtOAc);
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05648368 |
| Source dataset | uspto-grants-1997_07 |
| ORD ID | ord-b49c10adaa87459da85df6c54ad2374a |
| Source note | uspto-grants-1997_07 |