HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 4-[2-(N-Benzylimidazol-4-yl)ethyloxy]benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Methyl 4-[2-(1-Benzylimidazol-4-yl)ethyloxy]benzoate | HCID 18928610 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 4-[2-(N-Benzylimidazol-4-yl)ethyloxy]benzoic acid | HCID 15850757 | — |
Reaction Steps
A mixture of the ester 25-4 (170 mg, 0.51 mmol), CH3OH (10 mL), and 1N NaOH (5 mL) was stirred for 20 hours at ambient temperature. The cooled reaction mixture was acidified with 1N HCl (5 mL) and extracted with EtOAc. The EtOAc portion was concentrated to give 25-5 as a gelataneous solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05648368 |
| Source dataset | uspto-grants-1997_07 |
| ORD ID | ord-706bd961279a411c84650ee391878fb9 |
| Source note | uspto-grants-1997_07 |