HRID265897

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：NN(C[C@@H](C(=O)O)S(=O)(=O)c1ccccc1)C(=O)c1ccc(OCCc2cn(Cc3ccccc3)cn2)cc1

HCID67720996

未命名化合物

PRODUCTS

生成物

HCID67720996

未命名化合物

HCID86596525

Ethanol ammonium hydroxide water

C2H13NO3

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID23938

Palladium

溶剂HCID18963719

未命名化合物

PROCEDURE

实验过程

A mixture of 25-7 (94 mg, 0.17 mmol), 10% Pd/C (94 mg), and 4% formic acid/CH3OH (50 mL) was stirred under a hydrogen atmosphere at ambient temperature for 4 days. Filtration, concentration of the filtrate, and the flash chromatography (silica, 10:1:1 ethanol/H2O/NH4OH) gave 25-7 as a solid. TLC Rf =0.31 (silica, 10:1:1 ethanol/NH4OH/H2O);

WORKUP

后处理

filtrationFiltration, concentration of the filtrate

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-6e91b82776934849b5cf4cebab229be9
来源数据集: uspto-grants-1997_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05648368
来源说明: uspto-grants-1997_07

反应 SMILES

[CH2:1]([N:8]1[CH:12]=[C:11]([CH2:13][CH2:14][O:15][C:16]2[CH:39]=[CH:38][C:19]([C:20]([N:22]([NH2:37])[CH2:23][C@H:24]([S:28]([C:31]3[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=3)(=[O:30])=[O:29])[C:25]([OH:27])=[O:26])=[O:21])=[CH:18][CH:17]=2)[N:10]=[CH:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>[Pd].C(O)=O.CO>[CH2:14]([OH:15])[CH3:13].[OH2:15].[NH4+:8].[OH-:15].[CH2:1]([N:8]1[CH:12]=[C:11]([CH2:13][CH2:14][O:15][C:16]2[CH:39]=[CH:38][C:19]([C:20]([N:22]([NH2:37])[CH2:23][C@H:24]([S:28]([C:31]3[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=3)(=[O:29])=[O:30])[C:25]([OH:27])=[O:26])=[O:21])=[CH:18][CH:17]=2)[N:10]=[CH:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1