HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-[2-(N-Benzylimidazol-4-yl)ethyloxy]benzoyl-2(S)-phenylsulfonyl-amino-beta-alanine → 4-[2-(N-Benzylimidazol-4-yl)ethyloxy]benzoyl-2(S)-phenylsulfonyl-amino-beta-alanine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-[2-(N-Benzylimidazol-4-yl)ethyloxy]benzoyl-2(S)-phenylsulfonyl-amino-beta-alanine | HCID 67720996 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Formic acid methanol | HCID 18963719 | — |
| Product | 4-[2-(N-Benzylimidazol-4-yl)ethyloxy]benzoyl-2(S)-phenylsulfonyl-amino-beta-alanine | HCID 67720996 | — |
| Product | Ethanol ammonium hydroxide water | HCID 86596525 | — |
Reaction Steps
A mixture of 25-7 (94 mg, 0.17 mmol), 10% Pd/C (94 mg), and 4% formic acid/CH3OH (50 mL) was stirred under a hydrogen atmosphere at ambient temperature for 4 days. Filtration, concentration of the filtrate, and the flash chromatography (silica, 10:1:1 ethanol/H2O/NH4OH) gave 25-7 as a solid. TLC Rf =0.31 (silica, 10:1:1 ethanol/NH4OH/H2O);
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05648368 |
| Source dataset | uspto-grants-1997_07 |
| ORD ID | ord-6e91b82776934849b5cf4cebab229be9 |
| Source note | uspto-grants-1997_07 |