4-Phenylpiperidine-4-carboxamide monohydrochloride → 1-[2-[3-(Benzo[1,3]dioxol-5-yl)-1-(3,4,5-trimethoxy-benzoyl)-pyrrolidin-3-yl]-ethyl]-4-phenyl-piperidine-4-carboxylic acid amide

Participants

Role	Name	HCID	Charge
Reactant	4-Phenylpiperidine-4-carboxamide monohydrochloride	HCID 3017129	—
Reactant	2-[3-(Benzo[1,3]dioxol-5-yl)-1-(3,4,5-trimethoxy-benzoyl)-pyrrolidin-3-yl]-ethyl-methanesulfonate	HCID 86750913	—
Product	1-[2-[3-(Benzo[1,3]dioxol-5-yl)-1-(3,4,5-trimethoxy-benzoyl)-pyrrolidin-3-yl]-ethyl]-4-phenyl-piperidine-4-carboxylic acid amide	HCID 54440183	—

Reaction Steps

Prepare by the method of example 3.3 using 2-[3-(benzo[1,3]dioxol-5-yl)-1-(3,4,5-trimethoxy-benzoyl)-pyrrolidin-3-yl]-ethyl-methanesulfonate (8 mmol) and 4-phenyl-piperidine-4-carboxylic acid amide hydrochloride (12 mmol). Chromatograph on silica gel to give the title compound.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US05648366
Source dataset	uspto-grants-1997_07
ORD ID	ord-f9251a58c1014a6fa18f522dadfc4725
Source note	uspto-grants-1997_07