HRID265933

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID313

Hydrochloric Acid

ClH

结构：COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC.NC(=O)N1CCOCC1

HCID67648306

未命名化合物

PRODUCTS

生成物

结构：COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC.Cl.NC(=O)N1CCOCC1

HCID67562114

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

Prepare by the method of example 66.4 using 1-[2-[3-(3,4-dichloro-phenyl)-1-(3,4,5-trimethoxy-benzoyl)pyrrolidin-3-yl]-ethyl]-4-phenyl-piperidine-4-carboxylic acid morpholine-amide (2.34 g, 3.3 mmol) and dichloromethane saturated with hydrochloric acid (100 mL) to give the title compound: Rf =0.58 (silica gel, 10% methanol/dichloromethane).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-ab39dc798fce466098d546d1bd3cebc7
来源数据集: uspto-grants-1997_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05648366
来源说明: uspto-grants-1997_07

反应 SMILES

[N:1]1([C:7]([NH2:9])=[O:8])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[Cl:10][C:11]1[CH:12]=[C:13]([C:18]2([CH2:37][CH2:38][N:39]3[CH2:44][CH2:43][C:42]([C:48]4[CH:53]=[CH:52][CH:51]=[CH:50][CH:49]=4)([C:45]([OH:47])=[O:46])[CH2:41][CH2:40]3)[CH2:22][CH2:21][N:20]([C:23](=[O:36])[C:24]3[CH:29]=[C:28]([O:30][CH3:31])[C:27]([O:32][CH3:33])=[C:26]([O:34][CH3:35])[CH:25]=3)[CH2:19]2)[CH:14]=[CH:15][C:16]=1[Cl:17].Cl>ClCCl>[ClH:10].[N:1]1([C:7]([NH2:9])=[O:8])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[Cl:10][C:11]1[CH:12]=[C:13]([C:18]2([CH2:37][CH2:38][N:39]3[CH2:44][CH2:43][C:42]([C:48]4[CH:53]=[CH:52][CH:51]=[CH:50][CH:49]=4)([C:45]([OH:47])=[O:46])[CH2:41][CH2:40]3)[CH2:22][CH2:21][N:20]([C:23](=[O:36])[C:24]3[CH:29]=[C:28]([O:30][CH3:31])[C:27]([O:32][CH3:33])=[C:26]([O:34][CH3:35])[CH:25]=3)[CH2:19]2)[CH:14]=[CH:15][C:16]=1[Cl:17]