Potassium Carbonate → (4-Bromophenyl)(2-butylpyrazolo(1,5-a)pyridin-3-yl) methanone

HRID 266051Notes

Reaction equation

HRID 266051 reaction equation
C1(C)C=C(C)C=C(C)C=1S([O-])(=O)=O.[NH2:14][N+:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1.C(=O)([O-])[O-].[K+].[K+].[Br:27][C:28]1[CH:33]=[CH:32][C:31]([C:34](=[O:41])[C:35]#[C:36][CH2:37][CH2:38][CH2:39][CH3:40])=[CH:30][CH:29]=1>C(#N)C>[Br:27][C:28]1[CH:29]=[CH:30][C:31]([C:34]([C:35]2[C:36]([CH2:37][CH2:38][CH2:39][CH3:40])=[N:14][N:15]3[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=23)=[O:41])=[CH:32][CH:33]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 130282001-Aminopyridin-1-ium 2,4,6-trimethylbenzene-1-sulfonateHCID 544491361-(4-Bromophenyl) 2-heptyn-1-one

Product 1

HCID 21472334(4-Bromophenyl)(2-butylpyrazolo(1,5-a)pyridin-3-yl) methanone

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent2×

Procedure

A mixture of 2.5 g of N-aminopyridinium mesitylene sulfonate (prepared by Synthesis, 1977 page 1, TAMURA, et al.), 25 ml of acetonitrile and 3.5 g of potassium carbonate was stirred for 15 minutes at ambient temperature and then the 2.27 g of the product of Step A in solution in 25 ml of acetonitrile were added.

Sources & evidence

ORD record
ord-d2123bdfd32842ea96254be12f7b6689
Source dataset
uspto-grants-1997_07
Patent number
US05650414

Reaction notes

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