Hexane → HCID 19032459, compound

HRID 266055Notes

Reaction equation

HRID 266055 reaction equation
[N+](=[CH2:3])=[N-].[CH2:4]([C:8]1[C:19]([CH2:20][C:21]2[CH:26]=[CH:25][C:24]([Br:27])=[CH:23][CH:22]=2)=[C:11]2[CH:12]=[CH:13][C:14]([C:16]([OH:18])=[O:17])=[CH:15][N:10]2[N:9]=1)[CH2:5][CH2:6][CH3:7].CCCCCC.C(OCC)(=O)C>C(Cl)Cl>[CH2:4]([C:8]1[C:19]([CH2:20][C:21]2[CH:22]=[CH:23][C:24]([Br:27])=[CH:25][CH:26]=2)=[C:11]2[CH:12]=[CH:13][C:14]([C:16]([O:18][CH3:3])=[O:17])=[CH:15][N:10]2[N:9]=1)[CH2:5][CH2:6][CH3:7]

Participants

6

Reactant 4

HCID 8058HexaneHCID 8857Ethyl AcetateHCID 9550DiazomethaneHCID 70113918HCID 70113918, compound

Product 1

HCID 19032459HCID 19032459, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

100 ml of a solution of diazomethane in methylene chloride were added at ambient temperature to a suspension of 4 g of the product of Example 11 in 100 ml of methylene chloride and the solvent was eliminated at 40° C. under reduced pressure. Chromatography on silica was carried out (hexane: 80/ethyl acetate: 20) to obtain 3.7 g of the expected product melting at < or=50° C.

Workup

  1. customwas eliminated at 40° C. under reduced pressure

Sources & evidence

ORD record
ord-c381eb11f46d4d84a140358d0b18786f
Source dataset
uspto-grants-1997_07
Patent number
US05650414

Reaction notes

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