HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 266077Generated: October 27, 2026
3-Bromoaniline → 4-(3-Bromophenylamino)-3-ethoxycarbonyl-6-trifluoromethylquinoline
https://huagongshe.com/reaction/266077
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 3-Bromoaniline | HCID 11562 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Ethyl 4-chloro-6-(trifluoromethyl)quinoline-3-carboxylate | HCID 4322147 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 4-(3-Bromophenylamino)-3-ethoxycarbonyl-6-trifluoromethylquinoline | HCID 19032481 | — |
Reaction Steps
The reaction mixture of 270.0 mg of 4-chloro-3-ethoxycarbonyl-6-trifluoromethylquinoline and 150 mL of 3-bromoaniline in 4 mL ethanol was heated at 95° C. for 4 h. The reaction was then cooled in an ice-water bath and addid with 2 mL of 0.5N sodium hydroxide solution. The solid was filtered, washed with cold ethaol-water (2:1) and dried to provide 278.0 mg of the titled compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05650415 |
|---|
| Source dataset | uspto-grants-1997_07 |
|---|
| ORD ID | ord-47f0e2a705654b17855c3ae306d058a5 |
|---|
| Source note | uspto-grants-1997_07 |
|---|
