Diethylamine → HCID 67716358, compound

HRID 266146Notes

Reaction equation

Cl[CH2:2][C:3]1[C:12]([C:13]([O:15][CH2:16][CH3:17])=[O:14])=[C:11]([C:18]2[CH:23]=[CH:22][C:21]([Cl:24])=[CH:20][CH:19]=2)[C:10]2[C:5](=[CH:6][C:7]([O:27][CH3:28])=[C:8]([O:25][CH3:26])[CH:9]=2)[N:4]=1.[CH2:29]([NH:31][CH2:32][CH3:33])[CH3:30]>>[Cl:24][C:21]1[CH:20]=[CH:19][C:18]([C:11]2[C:10]3[C:5](=[CH:6][C:7]([O:27][CH3:28])=[C:8]([O:25][CH3:26])[CH:9]=3)[N:4]=[C:3]([CH2:2][N:31]([CH2:32][CH3:33])[CH2:29][CH3:30])[C:12]=2[C:13]([O:15][CH2:16][CH3:17])=[O:14])=[CH:23][CH:22]=1

Participants

Reactant 2

HCID 8021Diethylamine

HCID 10526136HCID 10526136, compound

Product 1

HCID 67716358HCID 67716358, compound

Procedure

According to the same manner as that described in Example 33, ethyl 2-chloromethyl-4-(4-chlorophenyl)-6,7-dimethoxyquinoline-3-carboxylate was reacted with diethylamine to give ethyl 4-(4-chlorophenyl)-2-(N,N-diethylaminomethyl)-6,7-dimethoxyquinoline-3-carboxylate. This compound was recrystallized from ethyl acetate - hexane. Colorless prisms, mp. 82°-83° C.

Sources & evidence

ORD record: ord-0b65eb73022c433dbe578e90a87b6fe9
Source dataset: uspto-grants-1997_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05650410

Reaction notes

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