N-Methylaniline → HCID 19032355, compound

HRID 266158Notes

Reaction equation

Cl[CH2:2][C:3]1[N:12]=[C:11]([C:13]2[CH:18]=[CH:17][C:16]([O:19][CH3:20])=[C:15]([O:21][CH3:22])[CH:14]=2)[C:10]2[C:5](=[CH:6][C:7]([O:25][CH3:26])=[C:8]([O:23][CH3:24])[CH:9]=2)[N:4]=1.[CH3:27][NH:28][C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1>>[CH3:22][O:21][C:15]1[CH:14]=[C:13]([C:11]2[C:10]3[C:5](=[CH:6][C:7]([O:25][CH3:26])=[C:8]([O:23][CH3:24])[CH:9]=3)[N:4]=[C:3]([CH2:2][N:28]([CH3:27])[C:29]3[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=3)[N:12]=2)[CH:18]=[CH:17][C:16]=1[O:19][CH3:20]

Participants

Reactant 2

HCID 7515N-Methylaniline

HCID 107856562-Chloromethyl-4-(3,4-dimethoxyphenyl)-6,7-dimethoxyquinazoline

Product 1

HCID 19032355HCID 19032355, compound

Procedure

According to the same manner as that described in Example 56, 2-chloromethyl-4-(3,4-dimethoxyphenyl)-6,7-dimethoxyquinazoline was reacted with N-methylaniline to give 4-(3,4-dimethoxyphenyl)-6,7-dimethoxy-2-(N-methyl-N-phenylaminomethyl)quinazoline. This compound was recrystallized from ethanol. Colorless needles, mp. 141°-143° C.

Sources & evidence

ORD record: ord-5b394a8f0d7c41a1894fc125d8adec3b
Source dataset: uspto-grants-1997_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05650410

Reaction notes

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