Dicyclohexylcarbodiimide → 2-Dimethylaminopyridine

HRID 266190Notes

Reaction equation

HRID 266190 reaction equation
[CH3:1][C@H]1OC(=O)C2C(O)=CC(O)=C(Cl)C=2CC(=O)C=CC=C[C@H]2O[C@H]2C1.C1C2C(COC(NC(C)CCCCCCCCCC(O)=O)=O)C3C(=CC=CC=3)C=2C=CC=1.[CH:58]1([N:64]=[C:65]=[N:66][CH:67]2[CH2:72][CH2:71][CH2:70]CC2)CCCCC1>O1CCCC1>[CH3:1][N:64]([C:65]1[CH:70]=[CH:71][CH:72]=[CH:67][N:66]=1)[CH3:58]

Participants

5

Reactant 3

HCID 10868DicyclohexylcarbodiimideHCID 11268547CID 11268547HCID 19033001HCID 19033001, compound

Product 1

HCID 218852-Dimethylaminopyridine

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Following a procedure similar to that described in Example 12, but using 67 mg of radicicol, 280 mg of 11-(9-fluorenyl)methoxycarbonylaminododecanoic acid, 10 ml of dry tetrahydrofuran, 132 mg of dicyclohexylcarbodiimide and a catalytic amount of dimethylaminopyridine, 194 mg of the title compound were obtained.

Sources & evidence

ORD record
ord-508e3f18ae4f4bdcbfe85868842928c4
Source dataset
uspto-grants-1997_07
Patent number
US05650430

Reaction notes

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