3,4-dihydro-2H-pyran → HCID 67706868, compound

HRID 266269Notes

Reaction equation

HRID 266269 reaction equation
[O:1]1[CH:6]=[CH:5][CH2:4][CH2:3][CH2:2]1.[NH2:7][C:8]1[CH:9]=[C:10]([CH:16]=[CH:17][CH:18]=1)[C:11]([O:13][CH2:14][CH3:15])=[O:12].[Cl:19][C:20]1[CH:25]=[CH:24][C:23]([S:26]([NH:29][C@@H:30]([CH2:34][OH:35])[C:31](O)=[O:32])(=[O:28])=[O:27])=[CH:22][CH:21]=1>>[Cl:19][C:20]1[CH:21]=[CH:22][C:23]([S:26]([NH:29][C@@H:30]([CH2:34][O:35][CH:6]2[CH2:5][CH2:4][CH2:3][CH2:2][O:1]2)[C:31]([NH:7][C:8]2[CH:18]=[CH:17][CH:16]=[C:10]([C:11]([O:13][CH2:14][CH3:15])=[O:12])[CH:9]=2)=[O:32])(=[O:27])=[O:28])=[CH:24][CH:25]=1

Participants

4

Reactant 3

HCID 80803,4-dihydro-2H-pyranHCID 11400Ethyl 3-aminobenzoateHCID 788546106111-13-1

Product 1

HCID 67706868HCID 67706868, compound

Procedure

The procedure described in Example 1 was repeated, except that dihydropyran (1.46 ml) and ethyl m-aminobenzoate (2.13 g) were successively reacted with (S)-2-(4-chlorobenzenesulfonylamino)-3-hydroxypropanoic acid (3 g) to obtain (S)-2-(4-chlorobenzenesulfonylamino)-N-(3-ethoxycarbonylphenyl)-3-(tetrahydropyran-2-yloxy)propanamide (2.3 g).

Sources & evidence

ORD record
ord-710722b5ddfb4102bd5c12aec937188d
Source dataset
uspto-grants-1997_07
Patent number
US05650428

Reaction notes

Loading…