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HRID266277

反应详情

EQUATION

反应方程式

HRID 266277 的结构方程式

REACTANTS

反应物

2
结构：O=S(=O)(Cl)c1ccc(Cl)cc1
HCID7398

Benzenesulfonyl chloride, 4-chloro-

C6H4Cl2O2S

结构：CCOC(=O)Cc1ccc(NC(=O)C(COC2CCCCO2)NC(=O)OCc2ccccc2)cc1
HCID19032873

未命名化合物

PRODUCTS

生成物

1
结构：CCOC(=O)Cc1ccc(NC(=O)C(COC2CCCCO2)NS(=O)(=O)c2ccc(Cl)cc2)cc1
HCID19032785

未命名化合物

收率 65.3%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：[Pd]
催化剂HCID23938

Palladium

Pd

PROCEDURE

实验过程

The procedure described in Example 15 was repeated, except that (RS)-2-(benzyloxycarbonylamino)-N-(4-(ethoxycarbonylmethyl)phenyl)-3-(tetrahydropyran-2-yloxy) propanamide (4.34 g) was hydrogenolyzed in the presence of 10% Pd-C, and then, reacted with 4-chlorobenzenesulfonyl chloride (3.87 g) to obtain (RS)-2-(4-chlorobenzenesulfonylamino)-N-(4-(ethoxycarbonylmethyl)phenyl)-3-(tetrahydropyran-2-yloxy)propanamide (3.07 g).