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HRID 266277作成日：2026年10月25日

4-Chlorobenzenesulfonyl chloride → (RS)-2-(4-chlorobenzenesulfonylamino)-N-(4-(ethoxycarbonylmethyl)phenyl)-3-(tetrahydropyran-2-yloxy)propanamide

https://huagongshe.com/reaction/266277

反応式

関与物質

役割名称HCID仕込み量
反応物4-Chlorobenzenesulfonyl chlorideHCID 7398—
反応物(RS)-2-(benzyloxycarbonylamino)-N-(4-(ethoxycarbonylmethyl)phenyl)-3-(tetrahydropyran-2-yloxy)propanamideHCID 19032873—
触媒PalladiumHCID 23938—
生成物(RS)-2-(4-chlorobenzenesulfonylamino)-N-(4-(ethoxycarbonylmethyl)phenyl)-3-(tetrahydropyran-2-yloxy)propanamideHCID 1903278565.3%

反応手順

The procedure described in Example 15 was repeated, except that (RS)-2-(benzyloxycarbonylamino)-N-(4-(ethoxycarbonylmethyl)phenyl)-3-(tetrahydropyran-2-yloxy) propanamide (4.34 g) was hydrogenolyzed in the presence of 10% Pd-C, and then, reacted with 4-chlorobenzenesulfonyl chloride (3.87 g) to obtain (RS)-2-(4-chlorobenzenesulfonylamino)-N-(4-(ethoxycarbonylmethyl)phenyl)-3-(tetrahydropyran-2-yloxy)propanamide (3.07 g).

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US05650428
出典データセットuspto-grants-1997_07
ORD IDord-c8a45c138df54d12bd808e98e009c05f
出典メモuspto-grants-1997_07