Hydrochloric Acid → HCID 19032860, compound

HRID 266313Notes

Reaction equation

[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH:11][CH:12]([CH2:28][N:29]2[CH:33]=[CH:32][N:31]=[CH:30]2)[C:13]([NH:15][C:16]2[CH:21]=[CH:20][C:19]([CH2:22][CH2:23][C:24]([O:26]C)=[O:25])=[CH:18][CH:17]=2)=[O:14])(=[O:10])=[O:9])=[CH:4][CH:3]=1.Cl>>[ClH:1].[C:24]([CH2:23][CH2:22][C:19]1[CH:20]=[CH:21][C:16]([NH:15][C:13](=[O:14])[CH:12]([NH:11][S:8]([C:5]2[CH:4]=[CH:3][C:2]([Cl:1])=[CH:7][CH:6]=2)(=[O:10])=[O:9])[CH2:28][N:29]2[CH:33]=[CH:32][N:31]=[CH:30]2)=[CH:17][CH:18]=1)([OH:26])=[O:25]

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 19032752HCID 19032752, compound

Product 1

HCID 19032860HCID 19032860, compoundYield 191.3%

Procedure

The procedure described in Example 92 was repeated, except that (RS)-2-(4-chlorobenzenesulfonylamino)-3-(1H-imidazol-1-yl)-N-(4-(2-methoxycarbonylethyl)phenyl) propanamide (74 mg) was hydrolyzed, and then reacted with HCl to obtain (RS)-N-(4-(2-carboxyethyl)phenyl)-2-(4-chlorobenzenesulfonylamino)-3-(1H-imidazol-1-yl)propanamide hydrochloride (74 mg).

Sources & evidence

ORD record: ord-2506bcc425dd441e80992323604f18dc
Source dataset: uspto-grants-1997_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05650428

Reaction notes

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