Hydrochloric Acid → HCID 67706802, compound

HRID 266314Notes

Reaction equation

[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH:11][C@@H:12]([CH2:27][N:28]2[CH:32]=[CH:31][N:30]=[CH:29]2)[C:13]([NH:15][C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([C:22]([O:24]CC)=[O:23])[CH:17]=2)=[O:14])(=[O:10])=[O:9])=[CH:4][CH:3]=1.Cl>>[ClH:1].[C:22]([C:18]1[CH:17]=[C:16]([NH:15][C:13](=[O:14])[C@@H:12]([NH:11][S:8]([C:5]2[CH:4]=[CH:3][C:2]([Cl:1])=[CH:7][CH:6]=2)(=[O:10])=[O:9])[CH2:27][N:28]2[CH:32]=[CH:31][N:30]=[CH:29]2)[CH:21]=[CH:20][CH:19]=1)([OH:24])=[O:23]

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 53886493HCID 53886493, compound

Product 1

HCID 67706802HCID 67706802, compoundYield 66.7%

Procedure

The procedure described in Example 92 was repeated, except that (S)-2-(4-chlorobenzenesulfonylamino)-N-(3-ethoxycarbonylphenyl)-3-(1H-imidazol-1-yl)propanamide (53.1 mg) was hydrolyzed, and then reacted with HCl to obtain (S)-N-(3-carboxyphenyl)-2-(4-chlorobenzenesulfonylamino)-3-(1H-imidazol-1-yl)propanamide hydrochloride (18.03 mg).

Sources & evidence

ORD record: ord-349851e1255d4d6094fb0adf0199b0b0
Source dataset: uspto-grants-1997_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05650428

Reaction notes

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